meRfi®-GM
Carcinogenesis / Oncogenesis / Tumorigenesis & Microbials / Microorganisms
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There are about 3.7 × 10H30 microbes living on earth
The International Agency for Research on Cancer (IACR) estimates that only 11 of the ~10H12 microbial species on earth directly cause cancer. However, it is assumed that about 20% of human cancers can be linked to microbial pathogens (Oncomicrobes)
Microorganisms, including bacteria, viruses, fungi, and parasites, can contribute to cancer development through various mechanisms:
Persistent Infection and Inflammation
Chronic infections can lead to continuous inflammation, causing DNA damage and mutations in host cells. This persistent state of da…
References (Sources)
- Cancer and the microbiota
- Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes
- Fusobacterium is associated with colorectal adenomas
- Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
- Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment
- Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
- Microbial metabolites are involved in tumorigenesis and development by regulating immune responses