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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Dendritic cells (DCs) & Short-chain fatty acids (SCFAs)

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The GPR109a-signaling dependent mechanism described for macrophages also applies to Dendritic cells (DCs)
Kayama & Takeda 2020

Dendritic cells (DCs) & Short-chain fatty acids (SCFAs)

Dendritic cells (DCs) uptake Short-chain fatty acids (SCFAs). This effect is dependent on the Na - coupled monocarboxylate transporter Slc5a8, which transports [butyrate](brain://RdqV-XIXjEO53KnjjHYYbA/ButyrateButyricAcidDendriticCellsDC…

Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases
Singh et al. 2010 Journal of Biological Chemistry. 285:27601-27608
Inhibition of histone deacetylase activity by butyrate
Davie et al. 2003 J Nutr 133 (7, Suppl):2485S–2493S.
Review
Manipulation of epithelial integrity and mucosal immunity by host and microbiota-derived metabolites
Kayama & Takeda 2020

5/29/2026