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The emergence of hypervirulent clade 2 Clostridioides difficile is associated with severe symptoms and accounts for >20% of global infections.
C. difficile clade 2 strains exclusively express two TcdB disease-causing toxin variants (TcdB2 and TcdB4) that use unknown receptors distinct from the classic TcdB.
Tissue factor pathway inhibitor (TFPI) is identified as the TcdB4 receptor.
Luo et al. …