Toll-like receptor 7 (TLR-7)

A SNP in TLR-7, a receptor for single-strand RNA, has been linked to ischemic stroke (45)
Brown & Hazen 2018 Nat. Rev. Microbiol. 16: 171-181

TLR-7 deficiency in an apoE -/- background worsens atherosclerosis (53)
Brown & Hazen 2018 Nat. Rev. Microbiol. 16: 171-181

What is TLR-7?

endosomal localisation

On which human immune cells is TLR-7 found?

B cells, plasmacytoid dendritic cells (pDCs), NK cells, Eosinophils,
Shekarian et al. 2017 Ann Oncol. 28(8): 1756-1766

On which human non-immune cells is TLR-7 found?

What are the ligands of TLR-7?

The immune response modifiers, imiquimod and resiquimod, are TLR-7 agonists that induce type I interferon in numerous species, including humans.
Gibson et al., 2002

ssRNA (viruses)

TLR-7 Agonists

Which consequences activation has?

Increase of cytokines that favor T cell recruitment and activation

TLR-7 signaling pathways are implicated in the regulation of immune system through type-I interferon induction
Patel & Minn 2018 Immunity 48: 417