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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Regenerating islet-derived protein 3 alfa (REG3A)

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Antimicrobial REG3 proteins are overproduced during inﬂammatory bowel disease perpetuate inﬂammation by depleting Enterococcus faecium from the microbiota. DL-endopeptidase SagA secreted by Enterococcus faecium activates myeloid NOD2 signaling to produce IL-1 beta, which induces the protective cytokine IL-22 from lymphoid cells
Jang et al. 2023 Cell Host & Microbe 31: 1450-1468

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References (Sources)

Antimicrobial overproduction sustains intestinal inﬂammation by inhibiting Enterococcus colonization
Jang et al. 2023 Cell Host & Microbe 31: 1450-1468
Regenerating islet derived 3-alpha is a biomarker of gastrointestinal graft-versus host disease
Ferrara et al. 2011 Blood 118(25): 6702-6708
Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease
Zhao et al. 2018e J Clin Invest. 128(11): 4970-4979

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5/29/2026

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Regenerating islet-derived protein 3 alfa (REG3A)

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