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Cardiometabolic diseases share common risk factors: Age, family history, unhealthy lifestyle habits (such as smoking, excessive alcohol consumption, unhealthy diet, obesity, and physical inactivity), and metabolic factors (such as high blood sugar, high triglyceride levels, large waist circumference, and high blood pressure).
Most epidemiological evidence suggests that high saturated fat intake increases the risk of diabetes and cardiovascular disease. However, the results of some recent studies (e.g., the PURE study) dispute this connection.
Diets high in saturated fatty acids (HFD) are widely used in rodent research to study the mechanism of insulin resistance and metabolic syndrome. Two separate, partially overlapping models exist: the [diacylglycerol](brain://pu503A0…