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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Innate immune receptors

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Innate immune receptors are required to promote long-term colonization by the microbiota.
Chu & Mazmanian 2013

As genetic polymorphisms of Innate Immune Receptors (such as nucleotide-binding oligomerization domain (NOD) 2/ CARD15 and toll-like receptor (TLR) 4 are considered major risk factors for IBD development
Franchimont et al. 2004 Gut. 53(7): 987–92
Brand et al. 2005 Inflamm Bowel Dis. 11(7): 645–52.
Browning et al. 2007 Am J Gastroenterol. 102(11): 2504–12
De Jager et al. 2007 Genes Immun. 8(5):387–97.
Lakatos et al. 2007 BMC Cancer. 7: 54

see also:
Pattern Recognition Receptors (PRRs)
[Toll-interleukin-1 receptor (TIR) homology domain](brain://ae_SPSdgRUm0fyK-FLUQQA/Tollint…

References (Sources)

Collaboration between the innate immune receptors dectin-1, TLRs, and Nods
Underhill 2007
Review
Graft-versus-host disease: Regulation by microbe-associated molecules and innate immune receptors
Penack et al. 2010 Blood 115: 1865-1872
Innate immune recognition of the microbiota promotes host-microbial symbiosis
Chu & Mazmanian 2013
The microbiome and cytosolic innate immune receptors
Liwinski et al. 2020 Immunol Rev 297: 207
Review
The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases
De Jager et al. 2007 Genes Immun. 8(5):387–97.
The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease
Brand et al. 2005 Inflamm Bowel Dis.11(7): 645–52.
Toll-like receptors in innate immunity.
Takeda & Akira 2005 Int Immunol 17: 1-14
Review

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Innate immune receptors

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