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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Mucosal-associated invariant T (MAIT) cells

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Mucosal-Associated Invariant T (MAIT) cells are a population of innate T cells that play a critical role in host protection against bacterial and viral pathogens.
Ryan et al. 2024 J Immunol 212(11): 1706

Upon activation, MAIT cells can rapidly respond via both TCR-dependent and -independent mechanisms, resulting in robust cytokine production.
Ryan et al. 2024 J Immunol 212(11): 1706

Mucosal-associated invariant T (MAIT) cells represent an abundant innate-like T cell subtype in the human liver
Ruf et al. 2023 Cell 186(17): 3686-3705

Mucosal-Associated Invariant T (MAIT) Cells are assigned crucial roles in regulating immunity and inflammation, yet their role in [liver cancer](brain://Xrflkpu4GU230rXD…

References (Sources)

Distinct activation thresholds of human conventional and innate-like memory T cells
Slichter et al. 2016 JCI Insight 1: e86292
Divergent metabolic programmes control two populations of MAIT cells that protect the lung
Riffelmacher et al. 2023 Nat. Cell. Biol. 25: 877-891
Human MAIT cells show metabolic quiescence with rapid glucose-dependent upregulation of granzyme B upon stimulation
Zinser et al. 2018 Immunol. Cell Biol. 96: 666-674
MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection
Meierovics et al. 2013 Proc. Natl. Acad. Sci. USA 110: E3119-E3128
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
Treiner et al. 2003 Nature 422: 164-169
Targeting mitochondrial dysfunction in MAIT cells limits IL-17 production in obesity
Brien et al. 2020 Cell. Mol. Immunol.17: 1193-1195
The proliferation of human mucosal-associated invariant T cells requires a MYCSLC7A5-glycolysis metabolic axis
Kedia-Mehta et al. 2023 Sci. Signal. 16: eabo2709

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Mucosal associated invariant T cell - Wikipedia