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Mucosal-associated invariant T (MAIT) cells
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Contents
Mucosal-Associated Invariant T (MAIT) cells are a population of innate T cells that play a critical role in host protection against bacterial and viral pathogens.
Upon activation, MAIT cells can rapidly respond via both TCR-dependent and -independent mechanisms, resulting in robust cytokine production.
Mucosal-associated invariant T (MAIT) cells represent an abundant innate-like T cell subtype in the human liver
Mucosal-Associated Invariant T (MAIT) Cells are assigned crucial roles in regulating immunity and inflammation, yet their role in [liver cancer](brain://Xrflkpu4GU230rXD…
References (Sources)
- Distinct activation thresholds of human conventional and innate-like memory T cells
- Divergent metabolic programmes control two populations of MAIT cells that protect the lung
- Human MAIT cells show metabolic quiescence with rapid glucose-dependent upregulation of granzyme B upon stimulation
- MAIT cells are critical for optimal mucosal immune responses during in vivo pulmonary bacterial infection
- Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
- Targeting mitochondrial dysfunction in MAIT cells limits IL-17 production in obesity
- The proliferation of human mucosal-associated invariant T cells requires a MYCSLC7A5-glycolysis metabolic axis