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Mucosal-Associated Invariant T (MAIT) cells are a population of innate T cells that play a critical role in host protection against bacterial and viral pathogens.
Upon activation, MAIT cells can rapidly respond via both TCR-dependent and -independent mechanisms, resulting in robust cytokine production.
Mucosal-associated invariant T (MAIT) cells represent an abundant innate-like T cell subtype in the human liver
Mucosal-Associated Invariant T (MAIT) Cells are assigned crucial roles in regulating immunity and inflammation, yet their role in liver cancer remains elusive.
The analyses highlight the heterogeneity and dysfunctionality of Mucosal-Associated Invariant T (MAIT) Cells in Hepatocellular Carcinoma (HCC) and their defective capacity to infiltrate liver tumors.
Patient samples and murine models reinvigorated Mucosal-Associated Invariant T (MAIT) Cells cytotoxicity. These studies suggest that aPD-1/aPD-L1 therapies target Mucosal-Associated Invariant T (MAIT) Cells in Hepatocellular Carcinoma (HCC) patients.
Mucosal-associated invariant T (MAIT) cells rely on glycolysis to support their production of Interferon Type II (IFN Type II) / Interferon Gamma (IFN-g) and granzyme B, while Interleukin-17 Family / Interleukin-17 (IL-17) production by MAIT cells has been linked to mitochondrial metabolism
Mucosal-associated invariant T (MAIT) cells are rapidly responsive T cells that can produce several cytokines, such as Interferon Type II (IFN Type II) / Interferon Gamma (IFN-g), Tumor Necrosis Factor alfa (TNF-alfa), and Interleukin-17 Family / Interleukin-17 (IL-17), upon activation
Mucosal-associated invariant T cells (MAIT) are a population of non-MHC-restricted T cells important for immune defense against bacterial and Viral infections
They can also be activated TCR-independently by stimulation with cytokines such as Interleukin-18 (IL-18)
Mucosal-associated invariant T (MAIT) cells are implicated in mucosal homeostasis and absent in germ-free mice.
Commensal Bacteria / Commensalism govern murine MAIT intrathymic development, as Mucosal-Associated Invariant T (MAIT) Cells did not recirculate to the thymus.
Mucosal-Associated Invariant T (MAIT) Cells development required RibD expression in bacteria, indicating that production of the MAIT antigen 5-(2-oxopropylideneamino)-6-Dribitylaminouracil (5-OP-RU) was necessary.
5-OP-RU rapidly traveled from mucosal surfaces to the thymus, where it was captured by the major histocompatibility complex class Ib molecule MHC Class I-Related Protein (MR1).
This led to increased numbers of the earliest MAIT precursors and the expansion of more mature receptor-related, orphan receptor gamma/t–positive Mucosal-Associated Invariant T (MAIT) Cells.
Mucosal-Associated Invariant T (MAIT) Cells are evolutionarily conserved T cells that recognize vitamin B2 precursor derivatives 5-(2-oxopropylideneamino)6-D-ribitylaminouracil (5-OP-RU) presented by the major histocompatibility complex class Ib molecule MHC Class I-Related Protein (MR1).
Mucosal-Associated Invariant T (MAIT) Cells have been implicated in human pathologies associated with microbiotal dysbiosis.
MAIT17 cells are Mucosal-associated invariant T (MAIT) cells that express Interleukin-17 Family / Interleukin-17 (IL-17). Their rapid development depends on colonization with Commensal Bacteria / Commensalism.
see also:
Hepatocellular Carcinoma (HCC)
Immune Checkpoint Inhibitors (ICIs) & Hepatocellular Carcinoma (HCC)