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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Sphingolipids

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Ceramides and sphingomyelins are composed of a sphingoid base and an N-acylated fatty acyl chain, which can vary in length. In mammalian cells, ceramides are generated with acyl tail lengths that fall into two categories:

Long Chain Sphingolipids: These have acyl tails of 14–18 carbons.

Very Long Chain (VLC) Sphingolipids: These have acyl tails of 20 or more carbons.
These sphingolipids can be either saturated (having no double bonds) or mono-unsaturated (having one double bond).

York et al. 2024 Nature 627: 628-635

Sphingolipid species with saturated and mono-unsaturated acyl tails ranging from 16 to 24 carbons are in macrophage samples. There are notable differences be…

References (Sources)

1,520 Reference Genomes from Cultivated Human Gut Bacteria Enable Functional Microbiome Analyse
Zou et al. 2019b Nat Biotechnol 37: 179-185
Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces
Abdel Hadi et al. 2016 Cell 165: 132
Review
IL-10 constrains sphingolipid metabolism to limit inflammation
York et al. 2024 Nature 627: 628-635
Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine
An et al. 2011 Proc. Natl Acad. Sci. USA 108(Suppl. 1): 4666–4671
Sphingolipids in hostmicrobial interactions
Heaver et al. 2018 Curr Opin Microbiol 43: 92-99

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Sphingolipids

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