meRfi®-GM
Sphingolipids
Welcome to meRfi-GM!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Navigation
Contents
Ceramides and sphingomyelins are composed of a sphingoid base and an N-acylated fatty acyl chain, which can vary in length. In mammalian cells, ceramides are generated with acyl tail lengths that fall into two categories:
- Long Chain Sphingolipids: These have acyl tails of 14–18 carbons.
- Very Long Chain (VLC) Sphingolipids: These have acyl tails of 20 or more carbons.
These sphingolipids can be either saturated (having no double bonds) or mono-unsaturated (having one double bond).
Sphingolipid species with saturated and mono-unsaturated acyl tails ranging from 16 to 24 carbons are in macrophage samples. There are notable differences be…
References (Sources)
- 1,520 Reference Genomes from Cultivated Human Gut Bacteria Enable Functional Microbiome Analyse
- Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces
- IL-10 constrains sphingolipid metabolism to limit inflammation
- Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine
- Sphingolipids in hostmicrobial interactions