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NFKB Signal transduction / NFKB Signal transduction pathway
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Scheme
The classic "canonical" NF-κB complex is a heterodimer of p50 and RelA. While in an inactivated state, NFKB is located in the cytosol complexed with the inhibitory protein IκB alpha. Through the intermediacy of integral membrane receptors, a variety of extracellular signals can activate the enzyme IκB kinase (IKK). IKK, in turn, phosphorylates the IκB alfa protein, which results in ubiquitination…
References (Sources)
- Gene Regulation
- Inflammation, atrophy, and gastric cancer
- Innate and adaptive effects of inflammasomes on T cell response
- NF-kappaB functions as a tumour promoter in inflammation-associated cancer
- Oscillations in NF-kappaB signaling control the dynamics of gene expression
- The G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Inhibits Gastric Inflammation Through Antagonizing NF-κB Signaling Pathway
- Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB