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The classic "canonical" NF-κB complex is a heterodimer of p50 and RelA. While in an inactivated state, NFKB is located in the cytosol complexed with the inhibitory protein IκB alpha. Through the intermediacy of integral membrane receptors, a variety of extracellular signals can activate the enzyme IκB kinase (IKK). IKK, in turn, phosphorylates the IκB alfa protein, which results in ubiquitination…