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Gut microbes enhance the activity of Anti-PD-1 antibodies / PD-1 inhibitors. Combination treatment of Bifidobacterium / Bifidobacter and a Anti-PD-1 antibodies / PD-1 inhibitors nearly abolished tumor outgrowth and decreased relapse. This effect was thought to be driven by the augmentation of dendritic cell function and accumulation of CD8+ T cells in the tumor microenvironment
Oral administration of Bifidobacterium alone improved tumor control to the …