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Enterococcus faecalis belongs to pathogenic bacteria. Patients with alcoholic hepatitis have increased fecal numbers of E. faecalis. E. faecalis cytolysin, a two-subunit exotoxin, is associated with the severity of liver disease and with mortality in those patients.
It causes direct lysis of hepatocytes and liver damage, likely through its ability to form pores.
Lang & Schnabl 2020 Cell Host & Microbe 28…