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The metabolism of choline involves several pathways:
During Phosphatidylcholine synthesis Choline is incorporated into phosphatidylcholine through the Kennedy pathway or the PEMT (phosphatidylethanolamine N-methyltransferase) pathway.
During Acetylcholine synthesis Choline acetyltransferase catalyzes the reaction between choline and acetyl-CoA to form acetylcholine.
Choline can be oxidized to betaine, which serves as a methyl donor
In addition, excess choline is broken down by [gut bacteria](brain://XiB1R7G6NUmX…