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HSF1 (Heat shock factor 1)

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Contents

Heat shock factor 1 (HSF1) is a master regulator of the heat shock response and plays a significant role in cancer. It supports various aspects of malignancy and has been investigated as a biomarker for patient outcomes in multiple cancer types. Small molecule inhibitors to reduce HSF1 activity have shown promise in suppressing tumor growth. Further development of HSF1 as a biomarker or therapeutic target is needed for clinical impact.
Carpenter & Gokmen-Polar 2019 Current Cancer Drug Targets 19: 515-524

see also:
Biomarker