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Host Defense / Immune system
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The Host Defense / Immune system can be differentiated in the systemic (nonmucosal) immune system and the common mucosal immune system
Elements of the adaptive immunity, including maternal antibodies and mucosal antibody responses, play crucial roles in protecting the hosts from pathogens in addition to promoting colonization of symbiotic bacteria at mucosal surfaces
Guzman-Bautista et al. 2020 Current Opinion Immunology 66: 82-89
Obesity and metabolic disease can influence the immune system
Michelet et a…
References (Sources)
- Fatty acid metabolites combine with reduced β-oxidation to activate Th17 inflammation in human type 2 diabetes
- Glycans as key checkpoints of T cell activity and function
- Inter-individual variation
- Metabolic reprogramming of natural killer cells in obesity limits antitumor responses
- Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
- STAT3 activation-induced fatty acid oxidation in CD8 +T effector cells is critical for obesity-promoted breast tumor growth
- Tissue immunometabolism: development, physiology, and pathobiology