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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Host Defense / Immune system

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The Host Defense / Immune system can be differentiated in the systemic (nonmucosal) immune system and the common mucosal immune system

Elements of the adaptive immunity, including maternal antibodies and mucosal antibody responses, play crucial roles in protecting the hosts from pathogens in addition to promoting colonization of symbiotic bacteria at mucosal surfaces
Guzman-Bautista et al. 2020 Current Opinion Immunology 66: 82-89

Obesity and metabolic disease can influence the immune system
Buck et al. 2017 Cell 169(4): 570–86
Man et al. 2017 Cell Metab. 25: 11–26
Geltink et al. 2018 Annu. Rev. Immunol. 36: 461-488
Michelet et a…

References (Sources)

Fatty acid metabolites combine with reduced β-oxidation to activate Th17 inflammation in human type 2 diabetes
Nicholas et al. 2019 Cell Metab. 30: 447–461
Glycans as key checkpoints of T cell activity and function
Pereira et al. 2018 Front Immunol 9: 2754
Review
Inter-individual variation
Brodin & Davis 2017
Metabolic reprogramming of natural killer cells in obesity limits antitumor responses
Michelet et al. 2018 Nat. Immunol. 19: 1330–1640
Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
Ringel et al. 2020 Cell 183: 1848-1866
STAT3 activation-induced fatty acid oxidation in CD8 +T effector cells is critical for obesity-promoted breast tumor growth
Zhang et al. 2020aa Cell Metab. 31: 148–161
Tissue immunometabolism: development, physiology, and pathobiology
Man et al. 2017 Cell Metab. 25: 11–26

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12/16/2025

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Host Defense / Immune system

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