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Wildling mice
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Wildling mice result from laboratory mouse embryos implanted into pseudopregnant wild mice.
They acquire complex wild mouse microbiota and pathogens not present in laboratory mice.
A unique advantage of wildling mice is that they are exposed to microbiota and pathogens early in life, allowing analysis of immunological phenotypes trained by the microbiota
In standard animal husbandry, mice are fed a grain-based chow, which contains natural ingredients, such as ground corn, wheat and oat, [soybean](brain://d9zw…
References (Sources)
- All you can feed: some comments on production of mouse diets used in biomedical research with special emphasis on non-alcoholic fatty liver disease research
- Laboratory mice born to wild mice have natural microbiota and model human immune responses
- Natural versus Laboratory World: Incorporating Wild-Derived Microbiota into Preclinical Rodent Models