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Osteocalcin helps improve motor deficits and reduces the loss of dopaminergic neurons in Parkinson's disease (PD) mice. It achieves this by enhancing the potential for microbial propionate production and activating the G-Protein Coupled Receptor 41 (GPR41) in enteric neurons .
The abundance of some gut microbes (e.g., Lachnospiraceae and Enterobacteriaceae) was…