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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Opioid receptor (Μu)

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In inflamed bowel tissue, there overexpression of mu receptors by CD4+ and CD8+ lymphocytes occurs
Chande et al. 2020 Inflamm Bowel Dis 26: 843-851

Blocking Opioid receptor (Μu) in colitis models reduces CD4+ lymphocytes and cytokines like Tumor Necrosis Factor alfa (TNF-alfa) and Interleukin-1 (IL-1) beta (IL-1F2)
Philippe et al. 2003 J Clin Invest 111: 1329-1338
Philippe et al. 2006 Gut 55: 815-823

Modulating the innate opioid axis could be, hypothetically, a potential treatment for [Crohn…

Alternative and Complementary Approaches for the Treatment of Inﬂammatory Bowel Disease: Evidence From Cochrane Reviews
Chande et al. 2020 Inflamm Bowel Dis 26: 843-851
Review
Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation
Philippe et al. 2003 J Clin Invest 111: 1329-1338
Mu opioid receptor expression is increased in inflammatory bowel diseases: implications for homeostatic intestinal inflammation
Philippe et al. 2006 Gut 55: 815-823

5/30/2026