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Tumor Necrosis Factor alfa (TNF-alfa)
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Tumor Necrosis Factor alfa (TNF-alfa) acts via Tumor necrosis factor receptor 1 (TNFR1)
The pro-inflammatory cytokine Tumor Necrosis Factor alfa (TNF-alfa) plays a crucial role in orchestrating the inflammatory response by promoting further production of cytokines and chemokines via TNFR1-induced NFKB activation.
Priem et al. 2020 Trends …
References (Sources)
- A20 and Cell Death-driven Inflammation
- Antagonists of TNF action: clinical experience and new developmentsReview
- Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: receptors, functions, and roles in diseases
- Production of complement components by cells of the immune system