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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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CD4+ CD25+ FOXP3 high Treg (peripherally induced) & Interleukin-2 (IL-2)

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IL-2 = key cytokine in CD4+ CD25+ FOXP3 high Treg (peripherally induced) expansion
Zeng et al. 2019 J. Immunol. Res. 2019: 1603758

Although Interleukin-2 (IL-2) is important for effector T cell function, it has been hypothesized that therapies blocking IL-2 signals weaken Treg cell activity, promoting immune responses.
Carmenate et al. 2018

IL-2, which is a growth factor for CD4+ CD25+ FOXP3 high Treg (peripherally induced), inhibits the generation of [CD4+ Th17 cells](brain://4YXHo2IIfUadDp_…

References (Sources)

Blocking IL-2 Signal In Vivo with an IL-2 Antagonist Reduces Tumor Growth through the Control of Treg Cells
Carmenate et al. 2018
Cutting Edge: Probiotics and Fecal Microbiota Transplantation in Immunomodulation
Zeng et al. 2019 J. Immunol. Res. 2019: 1603758
Review
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Laurence et al. 2007 Immunity 26: 371–81

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CD4+ CD25+ FOXP3 high Treg (peripherally induced) & Interleukin-2 (IL-2)

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