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The activation of Toll-Like Receptor 4 (TLR-4) signal transduction on activated stellate cells responds to low LPS (endotoxin) concentrations, leading to the development of fibrosis and cirrhosis.
The gut-liver axis results from a close anatomical and functional, bidirectional interaction between the gastrointestinal tract and the liver, primarily facilitated through [portal circulation.](brain://J5…