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MyD88 (Myeloid differentiation primary response 88) signaling

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MyD88 (Myeloid differentiation primary response 88) signalling drives the innate immune system's response to pathogens and cellular damage. It acts as the main adaptor protein for most Toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) family members, connecting receptor activation to downstream inflammatory signalling.
Into et al. 2010 J Biol Chem 285(46): 35759-69
Deguine & Barton 2014 F1000Prime Rep 6: 97
Zheng et al. 2020 Front Mol Neurosci 12: 314

Inflammatory Role of TLR-MyD88 Signaling in Multiple Sclerosis
Zheng et al. 2020 Front Mol Neurosci 12: 314
Review
MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deﬁcient mice
Hoshi et al. 2012 Nat Commun 3: 1120
MyD88: a central player in innate immune signaling
Deguine & Barton 2014 F1000Prime Rep 6: 97
Regulation of MyD88 aggregation and the MyD88-dependent signaling pathway by sequestosome 1 and histone deacetylase 6
Into et al. 2010 J Biol Chem 285(46): 35759-69