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Mw: 270 kD
CdtB is a genotoxin found in both Campylobacter jejuni and Clostridioides (Clostridium) difficile, though its role and characteristics differ slightly between the two bacteria.
Clostridioides (Clostridium) difficile toxin B (TcdB) induces neurogenic inflammation by targeting gut-innervating afferent neurons and pericytes through receptors, including the Frizzled receptors (FZD1, FZD2 and FZD7) in neurons and chondroitin sulfate proteoglycan 4 (CSPG4) in pericytes.
Clostridioides (Clostridium) difficile toxin B (TcdB) stimulates the secretion of the neuropeptides [substance P (SP)](brain://rlf…