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Clostridioides (Clostridium) difficile toxin B (TcdB, CdtB)
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Contents
Mw: 270 kD
CdtB is a genotoxin found in both Campylobacter jejuni and Clostridioides (Clostridium) difficile, though its role and characteristics differ slightly between the two bacteria.
Clostridioides (Clostridium) difficile toxin B (TcdB) induces neurogenic inflammation by targeting gut-innervating afferent neurons and pericytes through receptors, including the Frizzled receptors (FZD1, FZD2 and FZD7) in neurons and chondroitin sulfate proteoglycan 4 (CSPG4) in pericytes.
Clostridioides (Clostridium) difficile toxin B (TcdB) stimulates the secretion of the neuropeptides [substance P (SP)](brain://rlf…
References (Sources)
- C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation
- Carriage of CdtB Encoding Campylobacter spp., Salmonella enterica, and Yersinia entercolitica in Patients with Gastroenteritis and Irritable Bowel Syndrome
- Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells
- Enterotoxic Clostridia: Clostridioides difficile Infections
- RHO-GTPases and cancer
- TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile
- The role of toxin A and toxin B in the virulence of Clostridium difficile