Loading…

Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

G-Protein Coupled Receptor 43 (GPR43) & Neutrophils / Neutrophilic Granulocytes

Welcome to meRfi-GM!

Please register to continue your trial period!

meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.

Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.

Start your free trial and transform your understanding of the gut microbiota today!

G-Protein Coupled Receptor 43 (GPR43) & Neutrophils : Neutrophilic Granulocytes

In neutrophils, G-Protein Coupled Receptor 43 (GPR43) activation triggers chemotaxis. It may promote survival or apoptosis. It enhances superoxide production. This involves crosstalk with P2Y purinoceptor 2 (P2RY2). It also boosts Interleukin-1 (IL-1) beta (IL-1F2) cytokine production. In Group 3 ILCs (ILC3), G-Protein Coupled Re…

Deconstructing Mechanisms of Diet-Microbiome-Immune Interactions
Alexander & Turnbaugh 2020
Review
Effects of short chain fatty acids on effector mechanisms of neutrophils
Vinolo et al., 2009a Cell Biochem Funct. 27(1):48–55
G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation
Sina et al. 2009 J Immunol. 183(11): 7514–22.
Metabolic and inflammatory functions of short-chain fatty acid receptors
Bolognini et al. 2021
Short-chain fatty acids stimulate the migration of neutrophils to inflammatory sites
Vinolo et al., 2009 Clin Sci (Lond). 117(9): 331–8

5/29/2026