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G-Protein Coupled Receptor 43 (GPR43)
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Contents
GPR43 receptors are expressed in neutrophils, adipocytes, peripheral blood mononuclear cells, B lymphocytes, eosinophils, and pancreatic beta-cells
Hansen et al. 2017 J Med Chem 60(13):5638–5645
Human GPR43 binds to butyrate, acetate, and [propionate](brain://aKiMRIRZLE6K…
References (Sources)
- Development and characterization of a fluorescent tracer for the free fatty acid receptor 2 (FFA2/GPR43)
- GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3
- GPR43/ FFA2: physiopathological relevance and therapeutic prospects.
- Identification of a GPR41, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
- Microbiota metabolite short-chain fatty acids (SCAFs), GPCR, and inflammatory bowel diseases
- Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice
- The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids