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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

G-Protein Coupled Receptor 43 (GPR43)

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Human GPR43 binds to butyrate, acetate, and [propionate](brain://aKiMRIRZLE6K…

Development and characterization of a fluorescent tracer for the free fatty acid receptor 2 (FFA2/GPR43)
Hansen et al. 2017a J Med Chem 60(13):5638–5645
GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3
Zhao et al. 2018d Mucosal Immunol 11: 752-762
GPR43/ FFA2: physiopathological relevance and therapeutic prospects.
Bindels et al. 2013 Trends Pharmacol Sci 34: 226–232
Review
Identification of a GPR41, FFA2R, expressed on leukocytes and activated by short-chain fatty acids
Nilsson et al. 2003 Biochemical and Biophysical Research Communications. 303: 1047–1052
Microbiota metabolite short-chain fatty acids (SCAFs), GPCR, and inﬂammatory bowel diseases
Sun et al. 2017
Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice
Kim et al. 2013c Gastroenterology. 145(2): 396-406
The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
Brown et al. 2003 J. Biol. Chem. 278: 11312-11319

12/16/2025