Bile acids / Bile salts export pump (BSEP) / ATP-binding cassette, sub-family B member 11 (ABCB11)

Enterohepatic circulation is critically dependent on dedicated

• bile salt transporters (BSEP),


• Apical sodium-dependent BA transporter (ASBT), organic solute transporter alpha/beta (OST alpha/beta),


• sodium taurocholate co-transporting polypeptide (NTCP))

Schubert et al. 2017 Immunological Reviews 279: 23-35

The ATP-dependent transport of bile salts into the bile occurs through the bile salt export pump (BSEP), located in the canalicular membrane. At the same time, bile salt-dependent bile flow (BSDF) is stimulated.
Boyer 2013 Compr Physiol 3: 1035-78

see also:
Bile acids / Bile salts transporters