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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Fluorouracil (5-FU) & Gut microbiota

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Escherichia coli BW25113, Bifidobacterium longum, Citrobacter freundii and Enterococcus faecalis significantly modify Fluorouracil (5-FU) in vitro, allowing us to conclude that bacteria can metabolize the drug
Chrysostomou et al. 2023 Cancer Res 83 (7_Supplement): 5898

Chemotherapy with Fluorouracil (5-FU) causes an imbalance of gut microbiota (with a shift from [Commensal Bacteria / Commensalism](brain://JoSXA0TK2ESM5PZtwOCEiQ/CommensalBacteriaComm…

References (Sources)

5-Fluorouracil and irinotecan (SN-38) have limited impact on colon microbial functionality and composition in vitro
Vanlancker et al. 2017 PeerJ 5: e4017
Apoptosis, Dysbiosis and Expression of Inflammatory Cytokines are Sequential Events in the Development of 5-Fluorouracil-Induced Intestinal Mucositis in Mice
Hamouda et al. 2017 Basic Clin Pharmacol Toxicol. 121(3): 159-168
Gut microbiota-derived metabolism of 5-fluorouracil affects drug efficacy [abstract]
Chrysostomou et al. 2023 Cancer Res 83 (7_Supplement): 5898

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3/11/2026

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Fluorouracil (5-FU) & Gut microbiota

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