meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond
Fluorouracil (5-FU) & Gut microbiota
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Contents
Escherichia coli BW25113, Bifidobacterium longum, Citrobacter freundii and Enterococcus faecalis significantly modify Fluorouracil (5-FU) in vitro, allowing us to conclude that bacteria can metabolize the drug
Chemotherapy with Fluorouracil (5-FU) causes an imbalance of gut microbiota (with a shift from [Commensal Bacteria / Commensalism](brain://JoSXA0TK2ESM5PZtwOCEiQ/CommensalBacteriaComm…
References (Sources)
- 5-Fluorouracil and irinotecan (SN-38) have limited impact on colon microbial functionality and composition in vitro
- Apoptosis, Dysbiosis and Expression of Inflammatory Cytokines are Sequential Events in the Development of 5-Fluorouracil-Induced Intestinal Mucositis in Mice
- Gut microbiota-derived metabolism of 5-fluorouracil affects drug efficacy [abstract]