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Memory B cells
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Contents
Memory B cells are an essential reservoir for generating plasma cells during the secondary immune response. They exhibit heterogeneity in terms of isotype usage, immunoglobulin mutation content, and phenotypic marker expression.
Phenotypic subsets of memory B cells are defined by specific markers:
- Mice: CD273 (Programmed cell death 1 ligand 2 (PD-L2)), B7-1, and CD73 (5′-Nucleotidase / Ecto-5′-Nucleotidase (NT5E))
- Humans: CD27 (Tumor necrosis factor receptor superfamily member 7) and [F…
References (Sources)
- CD23(+)IgG1(+) memory B cells are poised to switch to pathogenic IgE production in food allergy
- Memory B cells and plasma cells: The differentiative continuum of humoral immunity
- Principles and therapeutic applications of adaptive immunity
- Type 2-polarized memory B cells hold allergen-specific IgE memory