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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Memory B cells

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Memory B cells are an essential reservoir for generating plasma cells during the secondary immune response. They exhibit heterogeneity in terms of isotype usage, immunoglobulin mutation content, and phenotypic marker expression.

Phenotypic subsets of memory B cells are defined by specific markers:

Mice: CD273 (Programmed cell death 1 ligand 2 (PD-L2)), B7-1, and CD73 (5′-Nucleotidase / Ecto-5′-Nucleotidase (NT5E))

Humans: CD27 (Tumor necrosis factor receptor superfamily member 7) and [F…

References (Sources)

CD23(+)IgG1(+) memory B cells are poised to switch to pathogenic IgE production in food allergy
Ota et al. 2024 Sci Transl Med 16(733): eadi0673
Memory B cells and plasma cells: The differentiative continuum of humoral immunity
Cancro et al. 2021 Immunol Rev 303:
Review
Principles and therapeutic applications of adaptive immunity
Chi et al. 2024a Cell 187(9): 2052
Review
Type 2-polarized memory B cells hold allergen-specific IgE memory
Koenig et al. 2024 Sci Transl Med 16(733): eadi0944

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12/16/2025

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Memory B cells

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