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The microbiota composition located in the normal esophagus is relatively conserved without distinct microbial preferences in the upper, middle, and lower esophagus. Six major phyla constitute the esophageal microbiota, including Firmicutes, Bacteroides, Actinobacteria, Proteobacteria, Fusobacteria, and TM7, similar to the oral microbiota. Streptococcus dominates the esophageal microbiota. However, the microbiota varies in different esophageal diseases compared to that in the healthy esophagus. The [type I](brain://e7lAvk6WFk6If8xTvfNmLQ/Ent…