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Toll-like receptor 2 (TLR-2)
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Contents
TLR-2 is localized on cell membranes dimerizes to TLR-1/2 or TLR-2/6 heterodimer after binding of ligands (e.g., diacyl lipopeptide). The TLR-2 receptor can, however, also be activated as a homodimer.
In the epithelial barrier, Toll-like receptor 2 (TLR-2) is expressed by Enterocytes / Intestinal Epithelial Cells (IECs) and enteroendocrine cells, both apical and basolateral
Gorecki et al. 2021 Translational Neurodegenera…
References (Sources)
- Endogenous ligands of TLR-2 and TLR-4: agonists or assistants?
- Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies
- Modulation of atherosclerosis in mice by Toll-like receptor 2
- The role of TLR2 in infection and immunity
- TLR2 and TLR4 in Parkinson’s disease pathogenesis: the environment takes a toll on the gut
- TLR2 looks at lipoproteins
- Toll-like receptors: critical proteins linking innate and acquired immunity