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TLR-2 is localized on cell membranes dimerizes to TLR-1/2 or TLR-2/6 heterodimer after binding of ligands (e.g., diacyl lipopeptide). The TLR-2 receptor can, however, also be activated as a homodimer.
In the epithelial barrier, Toll-like receptor 2 (TLR-2) is expressed by Enterocytes / Intestinal Epithelial Cells (IECs) and enteroendocrine cells, both apical and basolateral
Gorecki et al. 2021 Translational Neurodegenera…