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TLR-2 is localized on cell membranes and dimerizes to Toll-like receptor 1 (TLR-1) / Toll-like receptor 2 (TLR-2) heterodimer (TLR-1/TLR-2) or Toll-like receptor 2 (TLR-2) / Toll-like receptor 6 (TLR-6) heterodimer (TLR-2/TLR-6) after binding of ligands. The TLR-2 receptor can, however, also be activated as a homodimer.
In the epithelial barrier, Toll-like receptor 2 (TLR-2) is expressed by Enterocytes / Intestinal Epithelial Cells (IECs) and [enteroen…