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meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond

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Faecalibacterium prausnitzii

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Contents

GeneBankAC: FP929045, FP929046

Faecalibacterium prausnitzii is an abundant gut commensal with potent anti-inflammatory properties mediated through cytokine modulation, tight junction fortification, and epigenetic effects, making it a potential therapeutic target for Inflammatory Bowel Disease (IBD).

It is a member of Clostridium cluster XIVa
Guo et al. 2020b Journal of Animal Science and Biotechnology 11: 24

Abundance and Taxonomy

It is a species found in the healthy human gut microbiome, comprising around 3.52% of all gut species

It is more closely related…

References (Sources)

Clostridium species as probiotics: potentials and challenges
Guo et al. 2020b Journal of Animal Science and Biotechnology 11: 24
Review
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Sokol et al. 2008 Proc Natl Acad Sci USA 105: 16731-16736
Faecalibacterium prausnitzii promotes intestinal epithelial IL-18 production through activation of the HIF1α pathway
Fagundes et al. 2023 Front Microbiol 14: 1298304
Links between diet, gut microbiota composition and gut metabolism
Flint et al. 2015
Mucosa-associated Faecalibacterium prausnitzii phylotype richness is reduced in patients with inflammatory bowel disease
Lopez-Siles et al. 2015 Appl Environ Microbiol. 81: 7582-7592
Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn’s Disease
Takahashi et al. 2016 Digestion 93: 59-65
The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition
Chang et al. 2014 Proc. Natl. Acad. Sci. U. S. A. 111: 2247–2252

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