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Iron
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One essential nutrient is iron, which nearly all organisms require as a cofactor in metalloproteins that carry out essential cellular functions (e.g., DNA replication).
Iron inside cells is important for many processes like making DNA and helping mitochondria work. However, it can also cause a type of cell death called ferroptosis, which happens when certain reactive oxygen species (ROS) are involved. Lysosomes, known for breaking down and recycling materials, play a key role in managing iron levels in cells. They also help connect signals related to metabolism and cell deat…
References (Sources)
- Iron in infection and immunity
- Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine
- Nathan and Oski’s hematology of infancy and childhood
- Nutritional immunity: the battle for nutrient metals at the host-pathogen interface
- The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2
- The structure of salmochelins: C-glucosylated enterobactins of Salmonella enterica
- Xenosiderophore Utilization Promotes Bacteroides thetaiotaomicron Resilience during Colitis