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Ferroptosis
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Ferroptosis can be induced in various ways. These include Gpx4 deletion, S100A4 inhibition, and cancer nanovaccines. These methods improve the tumor microenvironment. They work well with immune checkpoint inhibitors. This is seen in liver cancer and melanoma models
Ferroptosis shows necrotic morphology. It is similar to necroptosis. Both can trigger immune responses. They are types of immunogenic cell death.
CD8+ T lymphocytes mediate ferroptosis. Their cel…
References (Sources)
- Apoptotic caspases suppress mtDNAinduced STING-mediated type I IFN production
- CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4
- CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
- Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade
- Ferroptosis: an iron-dependent form of nonapoptotic cell death
- Immunogenic cell stress and death
- Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity