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ATP
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Contents
Extracellular ATP is released from live cells in controlled conditions, as well as dying cells in inflammatory conditions, and, thereby, regulates T cell responses, including Th17 cell induction. Additionally, ATP is secreted by a subset of intestinal bacteria.
Tumor cells treated with chemotherapy - effective adjuvans primes antitumor T cell responses through released ATP
ATP is an agonist at P2X receptors and P2Y receptors
Nuttle & Dubyak 1994 J. Biol. Chem. 269…
References (Sources)
- ATP drives lamina propria Th17 cell differentiation
- Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade
- Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1
- Cryopyrin activates the inflammasome in response to toxins and ATP
- Differential Activation of Cation Channels and Non-selective Pores by Macrophage P2, Purinergic Receptors Expressed in Xenopus Oocytes
- Innate and adaptive effects of inflammasomes on T cell response
- T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP