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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

T cell responses

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Studies focus on a few microbes in mouse intestines. Each bacterium triggers a specific T cell program. Germ-free mice lack certain T cells. Colonization with segmented filamentous bacteria (SFB) or Clostridium species changes this. Candidatus Savagella (Segmented filamentous bacteria/SFB) leads to CD4+ Th17 cells. Clostridium leads to Inducible / Peripheral Regulatory T Cells (iTregs / pTregs)
Ivanov et al. 2…

Flt3 ligand induces tumor regression and antitumor immune responses in vivo
Lynch et al. 1997
ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses
Hecht et al. 2018 J Immunol 200: 2025
Induction of colonic regulatory T cells by indigenous Clostridium species
Atarashi et al. 2011
Induction of intestinal Th17 cells by segmented filamentous bacteria
Ivanov et al. 2009
On the role of antigen in maintaining cytotoxic T-cell memory
Kündig et al., 1996
Ox40 Costimulation Enhances the Development of T Cell Responses Induced by Dendritic Cells In Vivo
de Smedt et al., 2002
Tumor immunotherapy: Preclinical and clinical activity of anti-CTLA4 antibodies
Korman et al., 2005
Review

12/16/2025