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T cell responses
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Contents
Studies focus on a few microbes in mouse intestines. Each bacterium triggers a specific T cell program. Germ-free mice lack certain T cells. Colonization with segmented filamentous bacteria (SFB) or Clostridium species changes this. Candidatus Savagella (Segmented filamentous bacteria/SFB) leads to T helper 17 cell (Th17). Clostridium leads to Inducible / Peripheral Regulatory T Cells (iTregs / pTregs)
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References (Sources)
- Flt3 ligand induces tumor regression and antitumor immune responses in vivo
- ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses
- Induction of colonic regulatory T cells by indigenous Clostridium species
- Induction of intestinal Th17 cells by segmented filamentous bacteria
- On the role of antigen in maintaining cytotoxic T-cell memory
- Ox40 Costimulation Enhances the Development of T Cell Responses Induced by Dendritic Cells In Vivo
- Tumor immunotherapy: Preclinical and clinical activity of anti-CTLA4 antibodiesReview