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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Clostridium Cluster IV & RAR-related Orphan Receptor Gamma/T (ROR-gamma/t) Isoform 2 (NR1F3)t+ Foxp3+ Colonic Treg cells

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Especially Clostridium clusters IV and XIVa, which metabolize dietary fibers into Butyrate / Butyric acid, induce Regulatory T Cells (Tregs) development correlated inversely with colitis severity in a mouse model
Atarashi et al. 2011

see aslo:
[Clostridium cluster XIVa & RAR-related Orphan Receptor Gamma/T (ROR-gamma/t) Isoform 2 (NR1F3)t+ Foxp3+ Colonic Treg cells](brain://viLJhFH9L0aQaR5hhpejtw/Clos…

References (Sources)

Induction of colonic regulatory T cells by indigenous Clostridium species
Atarashi et al. 2011
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi et al. 2013 Nature 500: 232

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12/18/2025

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Clostridium Cluster IV & RAR-related Orphan Receptor Gamma/T (ROR-gamma/t) Isoform 2 (NR1F3)t+ Foxp3+ Colonic Treg cells

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