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Pharmacological or molecular inhibition of autophagy improves the efficacy of cytotoxic chemotherapy in murine models
Most forms of chemotherapy display a mour activity by targeting DNA integrity and Cell division in the dividing cancer cells
According to their mechanism of action, cytotoxic drugs are classified into alkylating agents, heavy metals including platinum, antimetabolites, cytotoxic antibiotics, and spindle poisons.
Cytotoxicity can also be achieved through the effects of drugs on mitochondria and cell membranes
The outcome of chemotherapy can be influenced by the host immune system at multiple levels.
After discovering the cytotoxic effects of nitrogen mustard during World War II, cytotoxic chemotherapeutic agents were developed that are still an essential part of cancer therapy today
Chemotherapy is non-specific, and its use is always associated with significant toxicity to tissues with a high rate of cell renewal and division