meRfi®-GM
Canonical Wnt signal transduction pathway / Wnt/Beta-catenin Pathway
Welcome to meRfi-GM!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Navigation
Contents
WNT signaling is fundamental. It regulates tissue homeostasis.
The canonical Wnt pathway (or Wnt/β-catenin pathway) is the Wnt pathway that causes an accumulation of beta-catenin in the cytoplasm and its eventual translocation into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family. Without Wnt, beta-catenin does not accumulate in the cytoplasm because a destruction complex typically degrades it.
When Wnt binds to its receptor "Frizzled" and the co-receptor "LRP" (Low-density lipoprot…
References (Sources)
- An updated overview on Wnt signaling pathways: a prelude for more
- Cadherins and Wnt signalling: a functional link controlling bone formation
- Enteric Bacteria and Cancer Stem Cells
- Inflammation and colon cancer
- Looking beyond the Wnt pathway for the deep nature of β‑catenin
- The Wnt–beta-Catenin–IL-10 Signaling Axis in Intestinal APCs Protects Mice from Colitis-Associated Colon Cancer in Response to Gut Microbiota
- WNT as a Driver and Dependency in Cancer