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WNT signaling is fundamental. It regulates tissue homeostasis.
The canonical Wnt pathway (or Wnt/β-catenin pathway) is the Wnt pathway that causes an accumulation of beta-catenin in the cytoplasm and its eventual translocation into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family. Without Wnt, beta-catenin does not accumulate in the cytoplasm because a destruction complex typically degrades it.
When Wnt binds to its receptor "Frizzled" and the co-receptor "LRP" (Low-density lipoprot…