Trefoil Factor 3

Trefoil Factor 3 (TFF3), or intestinal trefoil factor, is a peptide secreted by intestinal goblet cells, crucial for mucosal repair and protection in the gastrointestinal tract. It aids in epithelial restitution and wound healing, existing as a 59 amino acid homodimer, with expression regulated by food intake. TFF3 also modulates immune responses, influences cancer biology by affecting cell proliferation and resistance to apoptosis, and has roles in neuropeptide functions and airway remodeling in chronic obstructive pulmonary disease. Its therapeutic potential is being explored for diseases involving epithelial damage and obstructive airway conditions.
Kannan et al. 2010 Neoplasia 12(12): 1041-53
Barrera et al. 2012 Bosn J Basic Med Sci 12(4): 256-64
Ge et al. 2015 PLoS One 10(6): e0126924
Yang et al. 2022 Cell Death Dis 13(1): 62

see also:
Human Beta Defensin 2 (HBD2) & Trefoil Factor 3
Human Beta Defensin 4 (HBD4) & Trefoil Factor 3