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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Alfa-mannans

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Alfa-mannans can be identiﬁed by TLRs and C-type lectin receptors (Dectin1, Dectin-2 (CLEC6A), and Macrophage-inducible C-type lectin (MINCLE / CLEC4E))
Iliev et al. 2012 Science. 336: 1314–1317

Alfa-mannans stimulates Dectin-2 (CLEC6A). After recognition, spleen tyrosine kinase (SYK) and [caspase recruitment domain family member 9 (CARD9)](brain://hVOT-dAf2EWeu_BgiYXxDQ/Caspas…

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Discovery of α-(1→6)-linked mannan structures resembling yeast N-glycan outer chains in Aspergillus fumigatus mycelium
Kadooka et al. 2024 mSphere 9: e00100-24
Glucan and Mannan-Two Peas in a Pod
Korolenko et al. 2019 Int J Mol Sci 20(13): 3189
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism
Cuskin et al. 2015 Nature 517(7533): 165-169
Immunity to fungal infections
Romani 2011 Nat Rev Immunol. 11: 275-88
Review
Interactions between commensal fungi and the C-type lectin receptor dectin1 inﬂuence colitis
Iliev et al. 2012 Science. 336: 1314–1317

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5/29/2026

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Alfa-mannans

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