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Activation / Activators & Toll-like receptors (TLRs)

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Toll-like receptors (TLRs) activate inflammatory pathways leading to de novo cytokine and chemokine generation.

Of all PRRs, Toll-like receptors (TLRs) can detect most pathogen and damage signals and represent the organism's first line of defense
Squillace & Salvemini 2022 Trends in Pharmacological Sciences 43(9): 726

Activation of TLRs by specific ligands leads to the production of proinflammatory cytokines and [type…