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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

High-salt diet & Inflammatory Bowel Disease (IBD)

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Several studies have investigated the effects of salt on experimental colitis in various mouse models, suggesting that salt is a potential dietary risk factor for Inflammatory Bowel Disease (IBD). In addition, a high-salt diet could destroy the colonic barrier by reducing the expression of occludin, Zonula Occludens Protein-1 (ZO-1) and MUCIN-2 (MUC2) and aggravate [experimental colitis](brain://ACHeUgEks0yVpGgWB9JFBg/ExperimentalC…

Dietary Patterns and Gut Microbiota: the Crucial Actors in Inflammatory Bowel Disease
He et al. 2022a Adv Nutr doi: 10.1093/advances/nmac029
Review
Dietary salt exacerbates experimental colitis
Tubbs et al. 2017 J Immunol 199(3): 1051-9
High salt diet exacerbates colitis in mice by decreasing lactobacillus levels and butyrate production
Miranda et al. 2018 Microbiome 6(1): 57
High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice.
Wei et al. 2017 Oncotarget 8(1): 70-82
High-salt diet induces IL-17-dependent gut inflammation and exacerbates colitis in mice
Aguiar et al. 2017 Front Immunol 8: 1969
Identification and characterization of a novel association between dietary potassium and risk of Crohn’s disease and ulcerative colitis
Khalili et al. 2016 Front Immunol 7: 554
Review
Sodium chloride-enriched diet enhanced inflammatory cytokine production and exacerbated experimental colitis in mice
Monteleone et al. 2017 J Crohns Colitis 11(2): 237-45

5/29/2026