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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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TCRgamma/delta+ IELs

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Activated TCRgamma/delta+ IELs have the ability to secrete cytokines and chemokines, which in turn activate TCRalfa/beta+ IELs. This process initiates a more robust adaptive immune response.
Lavelle et al. 2010 Mucosal Immunology 3(1): 17-28
Hoytema van Konijnenburg et al. 2017 Cell 171(4): 783-794
Montalban-Arques et al. 2018 Inﬂammatory Bowel Diseases 24(8): 1649-1659

see also:
Innate lymphoid cells (ILCs)
Intraepithelial Lymphocytes (IELS)
[NOD-like receptors (NLRs)](brain:…

References (Sources)

Intestinal Epithelial and Intraepithelial T Cell Crosstalk Mediates a Dynamic Response to Infection
Hoytema van Konijnenburg et al. 2017 Cell 171(4): 783-794
The innate immune system in the gastrointestinal tract: role of intraepithelial lymphocytes and lamina propria innate lymphoid cells in intestinal inﬂammation
Montalban-Arques et al. 2018 Inﬂammatory Bowel Diseases 24(8): 1649-1659
Review
The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis
Lavelle et al. 2010 Mucosal Immunology 3(1): 17-28
Review

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12/16/2025

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TCRgamma/delta+ IELs

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