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Interleukin-35 (IL-35)

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IL-35 production in Treg cells is substantially increased after the co-culture with effector T cells and required for maximal Treg function in vitro and in vivo
Ohkura et al., 2010

Treg cells, but not conventional T cells, secrete a novel inhibitory cytokine, IL-35, which is a member of the IL-12 family and a heterodimer comprised of Ebi3 - Il12α/p35 heterodimer
Collison et al. 2007 Nature 450(7169): 566-569