Insulin Resistance & Non-alcoholic fatty liver disease (NAFLD)

NAFLD is associated with insulin resistance and insulin action disturbances, which promotes triglyceride accumulation (e.g., increased de novo lipogenesis).
Semova & Biddinger 2021 TIPS 42: 183

In addition, hepatic insulin resistance could promote hepatocyte injury and inflammation which leads to NASH.
Koopman et al. 2019 Aliment Pharmacol Ther. 50(6): 628-639

Insulin resistance seems to have a crucial role in the development of NAFLD by causing increased lipolysis at the adipocyte level, leading to an increased flux of non‐esterified fatty acids from adipose tissue to the liver.
Marchesini et al. 2001 Diabetes 50: 1844-1850
Abu-Shanab & Quigley 2010 Nat Rev Gastroenterol Hepatol. 7: 691-701