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Insulin Resistance & Non-alcoholic fatty liver disease (NAFLD)
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Contents
NAFLD is associated with insulin resistance and insulin action disturbances, which promotes triglyceride accumulation (e.g., increased de novo lipogenesis).
In addition, hepatic insulin resistance could promote hepatocyte injury and inflammation which leads to NASH.
Insulin resistance seems to have a crucial role in the development of NAFLD by causing increased lipolysis at the adipocyte level, leading to an increased flux of non‐esterified fatty acids from adipose tissue to the liver.
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References (Sources)
- Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
- Review article: can bugs be drugs? The potential of probiotics and prebiotics as treatment for non-alcoholic fatty liver disease
- The role of the gut microbiota in nonalcoholic fatty liver disease
- Triglycerides in Nonalcoholic Fatty Liver Disease: Guilty Until Proven Innocent